The 27-year-old rapper wore a bra top and jacket and was joined on stage by a team of dancers.
Ciara gyrated and rapped on stage while belting out the tune. Midway through, the tempo changed and Ciara took a seat on the steps to sing.
Nicki also kicked off the show with a duet with R&B singer Chris Brown.
The awards show was held at Nokia Theatre L.A. on Sunday (June 30) in Los Angeles.
Check out the performance below and follow TheImproper on Twitter for all the latest music updates.